SepaBean Flash Chromatography Systems | Innovative Separation Solutions

Flexible Flow Rate Options

Ranging from 1 mL/min to 1,000 mL/min to handle a variety of applications.
Robust Pressure Capabilities

Supporting up to 1,450 psi (99.9 bar), for even the most demanding separations.
Versatile Column Compatibility

From 4 g to 10 kg, ensuring adaptability for both small and large-scale operations.
Wireless Control

With iPad® integration and flexible wireless control, the system offers enhanced convenience and mobility, making it ideal for light-sensitive separation experiments or operations within isolators.

Comprehensive Detection Options

Including 200 - 400 or 200 - 800 nm UV, UV/Vis, and optional ELSD, to cover a wide range of compounds.
Built-in Separation Method Recommendation

The software has a built-in separation method database that automatically recommends the most appropriate separation method based on the key information entered by the user, thereby improving work efficiency.
21-CFR Part 11 Compliance

The FDA-compliant software (21-CFR Part 11) ensures suitability for pharmaceutical R&D and laboratories.
Local Network Data Sharing

Instruments network locally for seamless data sharing and resource optimisation.

Simplifying Method Development

TLC-to-Gradient

The SepaBean™ machine’s control software now includes a powerful TLC-to-Gradient feature, streamlining the entire sample preparation process. By simply inputting TLC data and sample loading amounts, the software automatically recommends the appropriate flash column and generates an optimized elution gradient. This innovation significantly accelerates workflows and enhances overall efficiency.

Step 1: TLC Rf Values
Method 1: Using a Picture of the TLC	Method 2: Input the RF Values manually
Click the camera icon to capture or select an image for Rf values. Adjust the solvent front and baseline manually. Selecting an Rf value auto-generates a gradient curve, or configure it manually.	Enter Rf values for target or impurities; the TLC graphic updates accordingly.

Step 2: Chromatography Run
In the settings tab, input key parameters for Flash method development. The software suggests a column based on sample weight or allows manual selection. Click the arrow to view recommendations and available columns.

HPLC-to-Gradient

High-performance liquid chromatography (HPLC) depends on precise elution gradients for accurate separation. Modern systems now automate gradient design by leveraging HPLC analysis data to recommend an optimized flash chromatography method as a starting point.

Step 1	Step 2
Enter the Analytical Data	Recommended Flash Chromatography Method
Enter the analytical HPLC data, including the sample retention time, the percentage of Solvent B at the elution point of a specific component, and the peak areas of both the target product and primary impurities.	The system will automatically generate the appropriate elution gradient based on this information.