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How to Select the Right Silica

The selection of the right stationary phase for liquid chromatography is dictated by 3 key factors:

Bulk-Flash-Selectivity

Solubility, molecular weight & difficulty of separation

Phase  Hydrophobic Hydrophobic Retention Hydrophilic Extremely Hydrophilic  Acidic Basic IEX
C18---NE ✔✔ ✔✔ ✔✔ ✔✔
C18 ✔✔ ✔✔✔ ✔✔ ✔✔ ✔✔
C18---HE ✔✔✔ ✔✔✔ ✔✔ ✔✔✔ ✔✔✔
C18---TNE ✔✔ ✔✔ ✔✔✔ ✔✔✔
C18---T ✔✔✔ ✔✔✔ ✔✔ ✔✔ ✔✔ ✔✔
C18---THE ✔✔✔ ✔✔✔ ✔✔✔ ✔✔✔
C18---A ✔✔✔ ✔✔✔
C18---A31 ✔✔ ✔✔ ✔✔ ✔✔ ✔✔ ✔✔
C8 ✔✔ ✔✔ ✔✔
C8---HE ✔✔✔ ✔✔✔ ✔✔
C8---A/A31 ✔✔✔ ✔✔✔
Phenyl ✔✔ ✔✔ ✔✔
C4 ✔✔
C4---HE ✔✔ ✔✔ ✔✔
C4---A/A31 ✔✔✔
Cyano ✔✔
DIOL ✔✔
Amino ✔✔✔ ✔✔ ✔✔✔
DNH ✔✔✔ ✔✔ ✔✔✔ ✔✔
PEI ✔✔✔ ✔✔✔ ✔✔✔ ✔✔✔
ARG ✔✔✔ ✔✔✔ ✔✔✔ ✔✔✔
COOH
SO3H ✔✔

Want to know more

If you want to find out more about Modus Bulk Silica, please get in touch with Chromatography Direct.

Semi-prep & Flash Chromatography Bulk Silica
Prep & Flash Chromatography Bulk Silica
HPLC Analytical Grade Bulk Silica
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Modus Granular Silica
Modus Micro Bead Silica
Modus Super Pure Silica
Modus Super Micro Bead Silica

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